| CASE REPORT |
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| Year : 2015 | Volume
: 29
| Issue : 2 | Page : 84-87 |
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Anti-centriole antibody: An infectious or autoimmune process?
Biman Saikia, Yashwant Kumar, Ranjana W Minz, Seema Chhabra
Department of Immunopathology, PGIMER, Chandigarh, India
Correspondence Address:
Seema Chhabra
Room No 29, 4th Floor, Research Block A, Department of Immunopathology, PGIMER, Sector-12, Chandigarh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0972-6691.178274
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Anti-centriolar pattern of staining by indirect immunofluorescence (IIF) on human epithelial type 2 (Hep2) cells is rarely observed, mostly in association with scleroderma and scleroderma-like connective tissue disorders. This paper describes four patients with anti-centriole antibody positivity along with a review of the available literature. In this retrospective study, a total of four cases whose serum showed the centriolar pattern on Hep2 cell lines during IIF examination were reviewed. The presence of anti-centriole antibody in the serum should herald the diagnosis of scleroderma spectrum; Raynaud's phenomenon and pulmonary arterial hypertension should be specifically looked for. In the absence of features of autoimmunity, patients should be screened for Mycoplasma infection. |
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