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Year : 2015  |  Volume : 29  |  Issue : 2  |  Page : 84-87

Anti-centriole antibody: An infectious or autoimmune process?

Department of Immunopathology, PGIMER, Chandigarh, India

Correspondence Address:
Seema Chhabra
Room No 29, 4th Floor, Research Block A, Department of Immunopathology, PGIMER, Sector-12, Chandigarh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-6691.178274

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Anti-centriolar pattern of staining by indirect immunofluorescence (IIF) on human epithelial type 2 (Hep2) cells is rarely observed, mostly in association with scleroderma and scleroderma-like connective tissue disorders. This paper describes four patients with anti-centriole antibody positivity along with a review of the available literature. In this retrospective study, a total of four cases whose serum showed the centriolar pattern on Hep2 cell lines during IIF examination were reviewed. The presence of anti-centriole antibody in the serum should herald the diagnosis of scleroderma spectrum; Raynaud's phenomenon and pulmonary arterial hypertension should be specifically looked for. In the absence of features of autoimmunity, patients should be screened for Mycoplasma infection.

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