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Year : 2018  |  Volume : 32  |  Issue : 1  |  Page : 24-27

Experimental study on the effect of Propolis injection Concentration to Anaphylaxis Shock

Department of Pharmacology, Pyongyang Medical College, Kim Il Sung University, Taesong District, Democratic People's Republic of Korea

Correspondence Address:
Dr. Jong-Hui Ri
Pyongyang Medical College, Kim II Sung University, Taesong District
Democratic People's Republic of Korea
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijaai.ijaai_38_16

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Purpose: To find the effect and mechanism of the action that the propolis injection concentration has on the anaphylactic shock, we made an anaphylactic shock model in guinea pig and found that the shock model guinea pig was recovered from the shock by the propolis injection concentration. We also studied the change of normal mast cell counts and the degranulation counts in a white rat mesentery and we found the effect on the change of the rat intestinal smooth muscular contraction by histamine so that we can explain the mechanism of the propolis action. Materials And Methods: The study methods are as follows: (1) The effect on the anaphylactic shock, (2) the experiment to establish the mechanism of the anaphylactic shock treatment by the propolis injection, (3) the experiment to establish the mechanism of the anaphylactic shock treatment by the propolis injection. Results: The Propolis Injection Concentration was found to increase the survival rate and decrease the counts of the degranulated cells remarkably in the rat mesentery after the anaphylactic shock. Conclusion: The propolis injection concentration shows the recovery of anaphylactic shock and it's mechanism is to block the histamine receptor and depress degranulation of the mast cell. Thus, it can be also used in the treatment of allergic asthma, conjunctivitis, urticaria.

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