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Year : 2020  |  Volume : 34  |  Issue : 1  |  Page : 23-27

Covid-19 immune mechanisms: A systematic review

1 Department of Physiology, KD Medical College, Hospital and Research Center, Mathura, Uttar Pradesh, India
2 Department of Biochemistry, KD Medical College, Mathura, Uttar Pradesh, India
3 Department of Community Medicine, KD Medical College, Mathura, Uttar Pradesh, India
4 Department of Physiology, KD Medical College, Mathura, Uttar Pradesh, India
5 Krishna Scan Center, Cuddalore, Tamil Nadu, India
6 Department of Radiology, Indraprastha Apollo Hospital, New Delhi, India
7 Department of Obstetrics and Gynaecology, Deen Dayal Upadhyay Hospital, Delhi, India

Correspondence Address:
Dr. Sandeep Kumar Sharma
Department of Biochemistry, First Floor, Academic Block, KD Medical College Campus, Akbarpur, Mathura-Delhi Highway, Mathura - 281 406, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijaai.ijaai_22_20

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There is a new public health crises threatening globally with the emergence and spread of 2019 novel coronavirus or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is the seventh member of the coronavirus (CoV) family, which infects humans and to which the Middle East Respiratory Syndrome CoV (MERS)-and SARS-CoV also belong. SARS-CoV-2 is a newly emerging human infectious CoV that causes COVID-19, which has been recognized as a pandemic by the World Health Organization on March 11. The most recent outbreak initially presented as pneumonia of unknown etiology as COVID-19 is a pneumonia-like disease with a group of symptoms including fever, dry cough and shortness of breath in a cluster of patients in December 2019 Wuhan, China. The body's immune system tries to protect the body from this pathogen. And as due to its surge in the body, various respiratory and other system-related complications increased. Therefore, in this article, COVID-19 immunopathogenesis is briefly reviewed. Through this review, we try to explain the molecular immune pathogenesis and diagnosis of COVID-19 (SARS-CoV-2) infection, based on the recent research progress of SARS-CoV-2 and the knowledge from researches on SARS-CoV and MERS-CoV.

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