Indian Journal of Allergy, Asthma and Immunology

: 2022  |  Volume : 36  |  Issue : 1  |  Page : 4--17

Management of drug allergy-clinical update

PC Kathuria1, Manisha Rai2 
1 National Allergy Centre, BLK Super Speciality Hospital, New Delhi, India
2 National Allergy Centre, New Delhi, India

Correspondence Address:
Dr. P C Kathuria
National Allergy Centre, 1/3 East Patel Nagar, New Delhi - 110 008

The new classification of drug hypersensitivity reactions (DHRs) is based on phenotypes, endotypes, and biomarkers. Immediate and delayed reactions are the clinical phenotypic presentation while endotypes are based on cellular, biological mediators, and biomarkers. Complement activation, cyclooxygenase-1 inhibition, Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2), Cytokine release syndrome (CRS) is also included in DHRs due to mast cell activation e.g., radio contrast media, nonsteroidal anti-inflammatory drugs, monoclonal antibodies, oxaliplatin and taxanes, etc. Genetic predisposition of specific human leukocyte antigen alleles has been associated with the development of T cell-mediated symptoms of severe cutaneous adverse reactions (SCAR), which includes acute generalized exanthematous pustulosis, drug rash with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necroplasia, due to antibiotics, retrovirus and anti-convulsant drugs, etc., drug desensitization (Ds), is a personalized treatment approach for immunoglobulin E (IgE), and Non-IgE mediated DHRs, for example, antibiotics, biologicals, chemotherapy, etc. This review will update on the mechanism of DHRs, the clinical approach of alternative drugs, and Ds in a high-risk patient.

How to cite this article:
Kathuria P C, Rai M. Management of drug allergy-clinical update.Indian J Allergy Asthma Immunol 2022;36:4-17

How to cite this URL:
Kathuria P C, Rai M. Management of drug allergy-clinical update. Indian J Allergy Asthma Immunol [serial online] 2022 [cited 2023 Mar 26 ];36:4-17
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